Toxin extrusion protein

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WebProtein toxins produced by bacteria represent novel and potent cytotoxic agents that may be coupled to specific carrier ligands used for cellular targeting. Current targeted toxins are … WebDec 5, 2005 · In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous …

Structure and function of multidrug and toxin extrusion

WebFig. 15. Amino acid sequences of sixteen selected toxins or toxin like peptides known or presumed to adopt a three-fingered fold. Toxins 1–4 are erabutoxins c, a, b, and d from … WebJul 11, 2024 · A transport assay of BBR using rat Madin–Darby canine kidney (MDCK)-multidrug and toxin extrusion protein 1 (rMate1) cells and a transcellular transport assay using MDCK-multidrug resistance protein 1 (MDR1) cells were conducted to evaluate the efflux mechanism. Tissue distribution and excretion of BBR were measured using liquid ... kaute foundation

MATE 1 Substrates DrugBank Online

WebApr 22, 2024 · Multidrug and toxin extrusion protein 1 (MATE1, gene symbol: SLC47A1) and the ATP-driven efflux pump P-glycoprotein (P-gp, gene symbol: ABCB1) are both expressed in the canalicular membrane of human hepatocytes and are described as transporters of organic cations. WebMATE1 (multidrug and toxin extrusion 1) Aliases: none Gene name: Solute carrier family 47 member 1 (SLC47A1) Summary MATE1 is an apically expressed poly-specific proton antiporter which mediates the efflux of diverse substrates, primarily organic cations, in the kidney and the liver. Web1 day ago · multidrug and toxin extrusion protein. MCP-1: monocyte chemoattractant protein. MDR: multidrug resistance protein. MMP: matrix metalloproteinase. MRP: multidrug resistance-associated protein. NF-κB: nuclear factor kappa B. NLRP3: nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3. Nox4: kaut-bullinger office + solution

MATE1 - Transporters - Solvo Biotechnology

Toxin Structure - an overview ScienceDirect Topics

WebJun 13, 2005 · Pharmacodynamics. Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid ... WebThe substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K were examined to find functional differences between these two transporters by the transfection of the cDNA of hMATE1 and hMATE2-K into HEK293 cells. kautex changchun plastic technology co. ltdMultidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47 member 1, is a protein that in humans is encoded by the SLC47A1 gene. SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes. kautex blow molding

"WebMultidrug and toxin extrusion protein 1 DrugBank Online Multidrug and toxin extrusion protein 1 Details Name Multidrug and toxin extrusion protein 1 Synonyms MATE-1 MATE1 Solute carrier family 47 member 1 Gene Name SLC47A1 Organism Humans Amino … " - Toxin extrusion protein

Toxin extrusion protein

WebOrganic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the l … Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats Phytother Res. 2024 Jun;32(6):1004-1013.doi: 10.1002/ptr.6036. Epub 2024 Feb 26. Authors WebProtein extrusion has frustrated earlier predictions regarding its impact in the development of food products. The main reason for this disappointing performance has been its failure …

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WebStructure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine 1 Dr. Margarete Fischer-Bosch … WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal tubular cells, …

WebNov 10, 2024 · A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions Authors Denise Türk 1 , Nina Hanke 1 , Thorsten Lehr 1 Affiliation 1 Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany. PMID: 33182761 PMCID: PMC7696733 DOI: … WebNov 18, 2007 · It is marketed under the brand name Klisyri. 12 Actinic keratosis is a chronic condition characterized by lesions, which can potentially transform into invasive squamous cell carcinoma with a risk of 1% over 10 years. 3, 7 Tirbanibulin blocks the molecular pathways that promote the proliferation, survival, and metastasis of malignant cells.

WebAug 31, 2024 · Twelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an … WebJan 9, 2009 · H+/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We have recently identified a regulatory ...

WebRenal effects: BIC is an inhibitor of organic cation transporter 2 and multidrug and toxin extrusion protein 1, so it decreases tubular secretion of creatinine. This increases serum …

WebJun 30, 2024 · Both uptake and efflux drug transporters are involved in kidney toxicity of some drugs. Source: reprinted from basit, radi, vaidya, karasu, prasad, ©2024. MATE, multidrug and toxin extrusion; MRP, multidrug resistance–associated protein; OAT, organic anion transporter; OCT, organic cation transporter; SGLT, sodium-glucose cotransporter. kautex group locationsWebAug 31, 2024 · Twelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an … kautex changchun plastic technology coWebMATE 1 Substrates Name MATE 1 Substrates Accession Number DBCAT003951 (DBCAT004044) Description Drugs that are eliminated by the MATE1 transporter, a multidrug and toxin extrusion transporter located in the apical membrane in the kidney and liver that is encoded by the SLC47A1 gene. Drugs Drugs & Drug Targets kautex guangzhou plastic technology co. ltdWebNov 15, 2013 · The nephrotoxicity limits the clinical application of cisplatin. Human organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATEs) work in concert in the elimination of cationic drugs such as cisplatin from the kidney. We hypothesized that co-administration of ondansetron … kautex blow molding machineryWebThere is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence and role in the ear are unknown. Aims/Objectives . Evaluate the presence and localization of MATE1, and determine the localization of OCT2, in the cochlea. Evaluate cisplatin uptake with regard to MATE1 and ... kautex cwc textronWebEpsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or type D. ETX belongs to the heptameric β-pore-forming toxins including aerolysin and … kautex headquartersWebDec 1, 2001 · Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), the drugs procainamide, … kautex shanghai plastic technology co. ltd