Iron metabolism in cancer
WebCancer cells exhibit an iron-seeking phenotype achieved through dysregulation of iron metabolic proteins. These changes are mediated, at least in part, by oncogenes and tumor suppressors. The dependence of cancer cells on iron has implications in a number of cell death pathways, including ferroptosis, an iron-dependent form of cell death. WebDec 27, 2024 · This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in …
Iron metabolism in cancer
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WebAug 8, 2024 · Cancer cells exhibit an iron-seeking phenotype achieved through dysregulation of iron metabolic proteins. These changes are mediated, at least in part, by oncogenes … WebNov 1, 2024 · Further studies regarding the mechanism of action and application of iron metabolism in lung cancer remain to be developed. 5. Perspectives and future directions. Lung cancer is the second most common cancer and the leading cause of cancer-related mortality among males and females worldwide [71]. Iron is an essential trace element in …
WebTransferrin (Tf) is an endogenous protein that transports iron into cells through the cell membrane's TfR. There is a growing body of evidence that TfR expression in HCC is much higher than that in healthy tissues because liver cancer cells show upregulated iron metabolism. Therefore, Tf has been utilized as a specific tumor-guiding unit to ...
WebLung cancer is a malignant lesion formed by the immortal proliferation of cancer cells with genetic mutations in the lungs. Lung adenocarcinoma is the most common type of lung cancer. Studies have shown that malignant cancer is usually related to dysregulated iron metabolism, especially the expression of iron metabolism genes. WebAug 5, 2024 · Iron chelators have long been a target of interest as anticancer agents. Iron is an important cellular resource involved in cell replication, metabolism and growth. Iron metabolism is modulated in cancer cells reflecting their increased replicative demands. Originally, iron chelators were first developed for use in iron overload disorders, however, …
WebDec 3, 2024 · In cancer patients, systemic iron metabolism is commonly altered. Moreover, cancer cells deploy diverse mechanisms to increase iron bioavailability to fuel tumor …
WebMar 24, 2024 · Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter, several disruptions of its metabolism occur at the steps of tumor initiation, progression and metastasis. Noticeably, cancer cells require a large amount of iron, and exhibit a strong dependence on it for their proliferation. population of india graphhttp://www.cacare.com/iron-and-cancer population of india in 1931WebJan 11, 2024 · Since iron adds to shaping major hallmarks of cancer, we emphasize innovative therapeutic strategies to address the iron pool of tumor cells or cells of the tumor microenvironment for the treatment of cancer. Keywords: iron chelators; iron homeostasis; lipocalin-2; macrophage polarization; tumor progression. Publication types Review MeSH … population of india in 1776WebJul 15, 2024 · Iron metabolism in hypoxic cancer cells involves iron intake, utilization and storage, and efflux, which are regulated by iron-related proteins [ 21 ]. The detailed … sharl perroWebSep 9, 2024 · Iron metabolism is considered central for glioma tumorigenesis, tumor progression and tumor microenvironment, although key iron metabolism-related genes are unclear. Here we developed and validated an iron … population of india chinaWebp53 is among the most critical tumor suppressor genes and is the most extensively studied gene in tumor biology within the past 40 years [1]. Due to its multiple functions in tumor, p53 has been recognized as a promising target to treat cancer [2]. In order to leverage the crucial roles of p53 in tumor therapy, it is necessary to illuminate the exact mechanisms for p53 … population of india compared to australiaWebMar 10, 2024 · A large number of studies suggest that intracellular iron metabolism disorders are related to the occurrence and development of tumors [9–12]. sharlows waddington