Web16 de jun. de 2015 · Here, we report that the E3 ubiquitin ligase VHL is essential for Treg cell function. Mice with Foxp3-restricted VHL deletion displayed massive inflammation … WebPesquisa de nif por ECV. O NIF.PT é um serviço gratuito para procurar, descobrir, consultar e validar o NIF de uma empresa ou de um gestor.
RSUME potentiates VHL mutants loss of function by decreasing …
WebHif-1α dominant-negative lentiviral vector was introduced into Hep3B cells to decrease the expression of Hif-1. to establish the lentiviral vector, a Hif expression vector for siHif-1α was manufactured using the multiSite-Gateway system (invitrogen, carlsbad, ca, uSa) according to the manufacturer's instructions. 293ft cells were transfected Web9 de abr. de 2024 · Here, we report that the oncogenic p73 isoform, ∆Np73, increases HIF-1α protein stability. We found that ∆Np73 represses expression of genes encoding … can chegg track what you\\u0027ve searched
ΔNp73 enhances HIF-1α protein stability through repression of …
Web1 de jul. de 2024 · The ECV complex is an E3 ligase complex responsible for polyubiquitinating HIF-1α. Loss of ∆Np73 increases ubiquitination of HIF-1α, leading to … WebThe hypoxia-inducible factor 1alpha (HIF-1alpha) is the master regulator of the cellular response to hypoxia. A key regulator of HIF-1alpha is von Hippel-Lindau protein (pVHL), which mediates the oxygen-dependent, proteasomal degradation of HIF-1alpha in normoxia. Here, we describe a new regulator o … WebThe institute is a constituent part of the Helmholtz-Zentrum Dresden-Rossendorf. It researches in the Resource Technology Topic within the Energy Efficiency, Materials, and Resources Program of the Helmholtz Association. HIF works in close collaboration with TU Bergakademie Freiberg and is a core member of the European EIT RawMaterials … fishing wynnum